CYTOTOXIC EFFECTS OF ARCTIUM MINUS METHANOL EXTRACT ON VARIOUS CANCER CELL LINES
نویسندگان
چکیده
Objective: This study aimed to evaluate the cytotoxic effects of Arctium minus (Hill) Bernh. ssp. methanol extract derived from aerial parts on cancer cell lines.Material and Method: For cytotoxicity assays, two different human breast lines (MCF-7 MDA-MB-231) healthy fibroblast line (MRC-5)as a control were used. Cell viability determination was performed using CellTiter-Blue method. One-Way ANOVA Tukey post test used for statistical analysis.Result Discussion: has been detected between ratios 27.8-38.7% MCF-7 line, significant activity observed via analysis (1 mg/mL treatment p< 0.022). However, 47.8-59.7% MDA-MB-231 MRC-5 did not demonstrate any (92.4-105.4% viability). Depending these data, treated with Arcitum extract, then by flow cytometry technique. The ratio death higher in (98%) compared (25%) after treatment. In conclusion, significantly decreased when MCR-5 normal line.
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ژورنال
عنوان ژورنال: Ankara Üniversitesi Eczac?l?k Fakültesi dergisi
سال: 2022
ISSN: ['1015-3918', '2564-6524']
DOI: https://doi.org/10.33483/jfpau.1084639